霍乱毒素B亚单位霍乱毒素B亚基_散射免疫扩散检测_免疫检测_生化试剂库_商城

货号：	abs80001
CAS号：	131096-89-4
供应商：	上海恒斐生物科技有限公司
数量：	现货
英文名：	霍乱毒素B亚单位霍乱毒素B亚基、CHOLERA TOXIN B SUBUNIT、CTB、 Cholera Toxin B subunit、CTxB、Choleragenoid
保存条件：	2-8 ºC
规格：	1mg

霍乱毒素B亚单位霍乱毒素B亚基、CHOLERA TOXIN B SUBUNIT、CTB、 Cholera Toxin B subunit、CTxB、Choleragenoid
规格1mg/2200元

描述

Cholera toxin （CTB,霍乱毒素B亚基）belongs to the AB5 –subunit family oftoxins.The native hexameric protein has a molecular mass of ~85 kDa and contains two subunits. It consists of a single A subunit (~27.2 kDa), responsible for the ADP-ribosylation activity, and five B subunits(~11.6 kDa each), which are arranged as a pentameric ring with an apparent 5-fold symmetry and are associated with the cell surface receptor binding and subsequent internalization (transmembrane transport)of the enzymatic component.

别名

霍乱毒素B亚基、CHOLERA TOXIN B SUBUNIT、CTB、 Cholera Toxin B subunit、CTxB、Choleragenoid

性能
保存方法	2-8 ºC
纯度	≥95%
分子量	11kd
溶解性	H2O: soluble 1mg/mL
CAS号	131096-89-4
外观	power
化学性质	2–8 °C, The product, as supplied, is stable 2 years when stored properly. Solutions are stable for at least 3 months when stored at 2–8 °C. DO NOT FREEZE.
技术指标	Format：Recombinant Source：E.coli Sodium azide：Not add.
产品用途	Cholera toxin and its purified A subunit are frequently used for the study of signal transduction mechanisms.In addition,cholera toxin acts as an adjuvant through the stimulation of B lymphocytes. The cholera toxin B subunit alone is used for track tracing in neurological research, taking advantage of GM1 ganglioside binding and retrograde transport.Tissue culture cells treated with cholera toxin are not killed and tissues of animals do not become necrotic.

参考文献
1. Nedelkoska, L., and Benjamins, J.A., Binding of cholera toxin B subunit: a surface marker for murine microglia but not oligodendrocytes or astrocytes. J. Neurosci. Res., 53, 605-612 (1998). 2. Janes, P.W., et al., Aggregation of lipid rafts accompanies signaling via the T cell antigen receptor. J. Cell Biol., 147, 447-461 (1999).

声明

The B subunit is non-toxic to cells and possesses no intrinsic adenylate cyclase activity. The cholera toxin B subunit (CTB) attaches to cells by binding to ganglioside GM1.8 CTB has been shown to be a good label for microglial cells (due to the enrichment of ganglioside GM1 on their cell surface), but not for oligodendrocytes or astrocytes. The B subunit has been reported to be an excellent tracer for the study of axonal transport using immunohistochemical methods. Recently it has been widely used as a marker of membrane lipid rafts, which are membrane microdomains enriched with cholestrol and sphingolipids. These lipid rafts have an important role in cell signaling and protein trafficking.

温馨提示：不可用于临床治疗。