ActinomycinD 放线菌素D

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货号: A4262
英文名: Actinomycin D
CAS号: 50-76-0
供应商: 广州华剑
保质期: 2年
数量: 大量
保存条件: 2-8℃
规格: 2mg
Actinomycin D 放线菌素D

 

 

英文名:Dactinomycin, Actinomycin D, ACTD

中文名:更生霉素,放线菌素D

CAS:50-76-0

说明:放线菌素D(Dactinomycin D)又称更生霉素,分子中含有一个苯氧环结构,通过它连接两个等位的环状肽链。此肽链可与DNA分子的脱氧鸟嘌呤发挥特异性相互作用,使 dactinomycin D嵌入DNA双螺旋的小沟中,与DNA形成复合体,阻碍RNA多聚酶的功能,抑制RNA的合成,特别是mRNA的合成。属于周期非特异性药物。一次静脉注 射给药后,很快从血浆消除,多数药物以原形经胆汁和尿液排出。抗瘤谱较窄,用于肾母细胞瘤、绒毛膜上皮癌、横纹肌肉瘤和神经母细胞瘤等。

Sigma相关产品资料:

SigmaA1410 Actinomycin D from Streptomyces sp.,

~98% (HPLC)

Synonym:

Actinomycin C1, Actinomycin IV, Dactinomycin

CAS Number:

50-76-0

Linear Formula:

C62H86N12O16

Molecular Weight:

1255.42

Beilstein Registry Number:

605235

EC Number:

200-063-6

MDL number:

MFCD00005033

PubChem Substance ID:

24890541

Description

Biochem/physiol Actions

An antineoplastic antibiotic that inhibits cell proliferation by forming a stable complex with DNA and blocking the movement of RNA polymerase which interferes with DNA-dependent RNA synthesis. Induces apoptosis. Potent antitumor agent. For cell culture applications, actinomycin D is used as a selection agent and is used in banding techniques to differentiate between different regions of chromosomes.

Caution

Hygroscopic and light sensitive.

性质

biological source

from Streptomyces sp.

assay

~98% (HPLC)

form

powder

color

red, powder

 

red to orange

mp

251-253

solubility

DMSO: 1 mg/mL

 

ethanol: soluble

storage temp.

2-8°C

安全性

Personal Protective Equipment

Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

Hazard Codes

T+

Risk Statements

28

Safety Statements

22-28-36/37-45

RIDADR

UN3462 6.1/PG 2

WGK Germany

3

RTECS

AU1575000 

温馨提示:不可用于临床治疗。