原癌基因酪氨酸蛋白激酶受体RET/多发性内分泌腺瘤和甲状腺髓样癌蛋白抗体

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单价: 600.00
品牌: WCYI
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更新: 2021-07-01
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货号: WC09517R
抗体英文名: Ret
浓度: 1mg/1ml
克隆性:
形态: Lyophilized or Liquid
亚型: IgG
免疫原: KLH conjugated synthetic peptide derived from human C1orf159
规格: 0.1ml
This gene, a member of the cadherin superfamily, encodes one of the receptor tyrosine kinases, which are cell-surface molecules that transduce signals for cell growth and differentiation. This gene plays a crucial role in neural crest development, and it can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Mutations in this gene are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma. Two transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their biological validity has not been confirmed. [provided by RefSeq, Jul 2008].
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