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重组人Tβ-4
附带条件
特技
胸腺素β4是由位于CHR上的TMSB4X基因编码的天然存在的肽。人类X。它在高浓度的血小板、伤口液和其他组织中被发现。Tβ4是一种重要的肌动蛋白调节肽，其主要功能是刺激T细胞的产生，这是免疫系统的重要组成部分。胸腺素β-4肽如果在心脏病发作后使用，可能会重新激活心脏祖细胞来修复受损的心脏组织。
附带条件
该材料由Sangon生物技术公司提供，用于研究、实验室或进一步评估目的。不适合人类使用。
附带条件
物理外观无菌过滤白冻干（冻干）粉末。
纯度为97%以上，采用SDS-PAGE和HPLC分析。
来源大肠杆菌。
与标准相比，生物活性完全具有生物活性。其在原代肺成纤维细胞中对过氧化氢产生保护作用的生物学活性在0.5～10μg/ml的浓度范围内。
从0.2μm过滤浓溶液中用20 mM Pb、pH 7.4进行冻干。
LaAl法测定内毒素低于1 EU /μg的RHUTβ4。
我们建议在打开之前将这个小瓶简单地离心，以将内容物带到底部。在含0.1% BSA的无菌蒸馏水或含水缓冲液中重组，浓度为0.1-1.0mg/mL。原料溶液应分摊到工作等分试样中，并储存在小于20℃的温度下，应在适当的缓冲溶液中进一步稀释。
AA序列SDKPDMAIE KFDKSKLKT ETKEQKNPLS KETEQEQEQA
概述
Thymosin Beta 4 is a naturally occurring peptide encoded by the TMSB4X gene located on Chr. X in humans. It is found in high concentrations in blood platelets, wound fluid and other tissues in the body. Tβ-4 is a major actin regulating peptide and the primary function is to stimulate the productions of T cells, which plays important part of the immune system. The thymosin beta-4 peptide, if used after a heart attack, might reactivate cardiac progenitor cells to repair damaged heart tissue.
使用说明
This material is offered by Sangon Biotech for research, laboratory or further evaluation purposes. NOT FOR HUMAN USE.
技术规格
| Physical Appearance | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Purity | > 97 % by SDS-PAGE and HPLC analyses. |
| Source | Escherichia coli. |
| Biological Activity | Fully biologically active when compared to standard. The biological activity determined by its ability to produce a protective effect against hydrogen peroxide in primary lung fibroblasts is in a concentration range of 0.5 - 10 μg/ml. |
| Formulation | Lyophilized from a 0.2 μm filtered concentrated solution in 20 mM PB, pH 7.4. |
| Endotoxin | Less than 1 EU/μg of rHuTβ4 as determined by LAL method. |
| Reconstitution | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions. |
| AA Sequence | SDKPDMAEIE KFDKSKLKKT ETQEKNPLPS KETIEQEKQA GES |
