货号: | WL02237 |
抗体名: | BECN1/Beclin1 抗体 |
抗体英文名: | BECN1/Beclin1 antibody |
浓度: | >1mg/ml |
应用范围: | WB,IHC |
宿主: | 兔 |
适应物种: | H,M,R |
标记物: | 无 |
克隆性: | 否 |
保存条件: | -20℃ |
形态: | 液体 |
亚型: | IgG |
规格: | 50μl(>50μg) |
本公司所有一抗,50μl(>50μg)现价450元/支,全部现货,均提供20μl免费试用装,详情请点击免费试用 产品货号 | WL02237 | 产品名称 | BECN1/Beclin1 Antibody | 预测分子量 | 60kDa | 别名 | ATG6; VPS30; beclin1 | 浓度 | >1 mg/ml | 免疫原 | 合成BECN1/Beclin1多肽 | 抗体来源 | 兔 | 特异性 | 抗人,小鼠,大鼠 | 克隆类型 | 多克隆抗体 | 产品应用 | WB;IHC | 成分 | 亲和纯化抗体,20 mM PBS,150 mM NaCl,100 μg/ml BSA,50%甘油,NaN3<0.02% | 保存条件 | -20℃保存 | 背景资料 | Beclin 1 participates in the regulation of autophagy and has an important role in development, tumorigenesis, and neurodegeneration. Beclin 1 can complement defects in yeast autophagy caused by loss of Apg6 and can also stimulate autophagy when overexpressed in mammalian cells. Autophagy is a catabolic process for the autophagosomic-lysosomal degradation of proteins activated in response to nutrient deprivation and in neurodegenerative conditions . One of the proteins critical to this process is Beclin 1, the mammalian orthologue of the yeast autophagy protein Apg6/Vps30. Mammalian Beclin 1 was originally isolated in a yeast two-hybrid screen for Bcl-2 interacting proteins and has been shown to interact with Bcl-2 and Bcl-xL, but not with Bax or Bak. | | | | | | | | | |
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温馨提示:不可用于临床治疗。