| 货号： | WC02173R |
| 抗体英文名： | phospho-B-Raf (Ser444) |
| 浓度： | 1mg/1ml |
| 克隆性： | 否 |
| 形态： | Lyophilized or Liquid |
| 亚型： | IgG |
| 免疫原： | KLH conjugated synthetic peptide derived from human IBRDC1 |
| 规格： | 0.1ml |
The Raf kinases are important intermediates in signal transduction. Raf protein family members, including A Raf and B Raf, have intrinsic serine/threonine kinase activity. Interaction between Ras proteins and Raf proteins results in Raf-mediated phosphorylation and activation of MEK (also known as MAP kinase kinase). Defects in BRAF are involved in a wide range of cancers. B-Raf is a serine/threonine protein kinase that acts as a signal transducer from membrane-associated receptors to nuclear transcription factors. 1 BRAF is important for the regulation of cell proliferation and determination of cell fate during embryogenesis. BRAF acts downstream of Ras and upstream of MEK in the Ras-Raf-MEK-ERK signal transduction pathway, which is a conserved RAS-activated protein kinase cascade that regulates cell growth, proliferation, and differentiation in response to growth factors, cytokines, and hormones.
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